Our discovery that ionomers such as polystyrene sulfonate were inhibitors of inflammatory cell proteases, including high isoelectric point proteases and metalloproteinases, known to populate inflamed and infected wounds, led to the genesis of the antimicrobial ionomer, silver polystyrene sulfonate and other cation-modified ionomers. These silver-based ionomers were later color stabilized using chemical associates with thiols including glutathione. Later, we discovered that this association with a thiol greatly reduced the tissue-related toxicity of ionic silver and allowed for the synthesis and isolation of numerous new silver thiolates, the GlutAgasept™ family of antiseptics.
The same chemical concepts were later applied to strong and weak ion exchange resins and with refined particle size reduction and incorporation into a variety of polymer matrices, the concept of self-disinfecting surfaces protected by GARDION™ Antimicrobials had arrived. The picture off to the right contains four individual members of our GARDION™ Antimicrobial resin family, each with its own unique set of properties.
The Iasis Molecular Sciences wound care business product pipeline includes the following:
- GARDION™ Advanced Foam Dressing
- GlutAgasept™ Advanced Foam Dressing
- GlutAgasept™ Wound Irrigation Fluid
- GlutAgasept™ Amorphous Wound Gel
- GARDION™ Wound Drainage Catheter
- GARDION™ Wound Contact Layer